What is conditioning/ Chemotherapy and radiation therapy before bone Marrow Transplant and Peripheral Blood Stem Cell Transplant?
The first step to BMT and PBSCT is destroying the diseased cells from your body through high doses of chemotherapy or radiation called conditioning. At Aster Medcity, we have the most advanced technology for these procedures, including Kerala’s first True Beam Linear Accelerator and dedicated radiotherapy rooms to ensure maximum patient safety. All radiotherapy treatments we provide are based on NCCN (USA) and ESMO (Europe) guidelines.
As cancerous cells divide faster than healthier cells, we can, through conditioning destroy the existing bone marrow cells so that we can infuse healthy, transplanted cells into your body effectively.
How are healthy, transplanted cells infused?
You will be infused with healthy, transplanted cells in the BMT unit through an IV line – just like you’d be on drips. As there will be no disease -fighting white blood cells and blood-clotting platelets after the conditioning, your susceptibility to infections will be extremely high. You’ll need to be extremely careful so that you don’t contract any infection and follow the doctor’s advise meticulously to avoid any complications.
Since the stem cells used for autologous transplantation should relatively be free of cancer cells, the harvested cells can sometimes be treated before transplantation in a process known as “purging”. This process removes maximum cancer cells from the harvested cells and minimise the chance of reoccurrence.
What are the possible post-transplant complications?
Apart from susceptibility to infection and bleeding, you may experience short-term side effects such as nausea, vomiting, fatigue, loss of appetite, mouth sores, hair loss, and skin reactions.
There are also potential long-term issues that your doctor will explain in detail to you before beginning the treatment.
What leads to the need for heart transplant in children?
Children and infants are also highly susceptible to heart disease and might require heart transplant due to severe cardiomyopathy (weak heart muscles) and congenital heart disease that cannot be medically managed. Some children who have already undergone corrective cardiac surgeries might also require heart transplant due to re-occurrence of problems (continued cardiac problems).
Who gives you your new heart?
The donor from whom you get a new heart is usually someone who would have signed up for organ donation before he or she died.
The heart is surgically removed, with the full consent of the donor’s family, once the donor is certified brain-dead.
The availability of donor organs are informed through an organ sharing network and the recipient is chosen based on the best possible match – with respect to the blood type, body type, recipient’s medical condition, and the waiting period.
The religion/ race/ gender of the donor or the recipient does not matter (in any organ transplant for that matter) while determining the match.
All donors are mandatorily screened for Hepatitis B and C and for HIV.
When it comes to paediatric heart transplants, we make sure that your child gets the best care possible. Our team of experts comprises Paediatric Cardiac Surgeons and Paediatric Interventional Cardiologists with decades of experience to their credit. We have specialised, state-of-the-art facilities for this programme including a Level 3 PICU that’s managed by internationally trained paediatric intensivists.
Waiting for a heart can be quite distressful, but if everything goes well, it’s definitely a second chance at life.
How is the heart transplant done?
Once a donor heart becomes available and all other factors are ascertained favourable, our entire transplant team gets ready for the surgery.
Our transplant surgeon will remove the diseased heart of the patient, except the back walls of the atria - the heart’s upper chambers.
The backs of the atria of the donated heart are opened and sewn into place; and blood vessels are connected, allowing the blood to flow to the heart and lungs. As the heart warms up, it starts beating.
You’ll be able to sit up and walk within a few days after the surgery, and if there are no signs of organ rejection, you can go home in probably about two weeks.
What is minimally invasive spine surgery (MISS) or keyhole spine surgery?
Minimally invasive spine surgery is a highly advanced spine surgery technique using very small incisions, using cutting-edge intra-operative technology.
What is spinal stenosis decompression
The narrowing of the spaces within the spine is known as spinal stenosis. The minimally invasive spine surgery procedure helps decompress the nerves in the narrow spaces between the vertebral bones and spinal joints.
Who can undergo scoliosis / spinal deformity surgery?
Children, adolescents with scoliosis
Patients with kyphosis (hunchback / forward curving of the spine)
Adults and elderly patients with spinal deformities
How long does it take to recover from scoliosis surgery?
If the recovery is as expected, the patient can be discharged within a week
Children can get back to school about a month after the surgery
What information does SUDOSCAN provide?
SUDOSCAN gives you the information about the small fiber nerve functions. In a SUDOSCAN test, electrical conductance of the hands and feet are measured. Test results with high conductance means normal sweat function whereas low conductance indicates peripheral or autonomic neuropathy.

