What is Kidney Transplant?
Kidney transplant is the process of replacing the diseased kidney with a healthy, donated kidney. It is recommended only if the kidneys are so damaged that they cannot be managed medically (Chronic Kidney Disease or End Stage Renal Disease).
In some cases, transplant might not be a practical solution if the patient has an active infection or another life-threatening disease such as cancer, severe heart or lung diseases.
Fortunately, according to worldwide figures, the success rate of kidney transplant is above 95%. This not only comes as a reassurance for those opting for transplant, but also reaffirms the fact that kidney transplant is indeed an effective mode of treatment.
What are the types of kidney transplant?
There are two types of kidney transplants: Live donor Transplant and Cadaver Transplant
When a person is transplanted with a kidney from a live donor, it is called Live Donor Transplant. The donor could be anyone - a family member, friend, colleague or even a random person who is generous enough to gift life by donating one of his/ her kidney.
Usually, the success rates of kidney transplants in which the donor and recipient belong to one family (parent/ sibling) are higher. This is because of high donor-recipient compatibility, which means the chances of rejection are very low. A live donor makes things easy as the waiting period is lesser and the patient gets well faster.
Cadaver transplant is when the kidney is got from a donor who is certified brain-dead. He or she would have would have signed up for donation before death. The kidney is surgically removed after obtaining consent from the deceased’s family and transplanted in the recipient.
What are the pre-transplant formalities?
You will have to go through a series of investigations before the surgery to ensure that the donor kidney matches your tissue and blood type. You will also be screened for other health problems including heart or lung diseases.
After these tests, you will be enlisted on the transplant list and also on the organ sharing network list. As soon as a matching recipient is available, we will let you know; and if all factors are favourable, our entire team will work as one to ensure you undergo the surgery without any issues.
What are the possible post-transplant risks?
The post-surgical risks, like every other transplant surgery, include rejection, infection, bleeding or reaction to anaesthesia.
Rejection happens when the body fails to recognise the new kidney and fights to destroy it. During the first few weeks or months post-surgery, your body may try to reject your new kidney. This is called acute rejection and occurs in 25 - 55% of the recipients. You’ll be given immuno-suppressants to counter this problem. Remember, it is mandatory to continue these medicines for the rest of your life.
There is also a chance of chronic rejection - a gradual, progressive loss of kidney function that may occur over many years. Unfortunately, there’s no known treatment for chronic rejection and the patient may have depend on dialysis again or opt for another transplant.
Aster Centre of Excellence in Multi-Organ Transplant has a very strong infection control system that’s managed by a highly-trained team of infectious diseases & infection control Physicians. Besides, we also have advanced technology like the HEPA Filter that purifies air to 0.3 microns, creating a safe and sterile environment for the patient.
What will it be like after the surgery?
You’ll be under continuous medical observation for 7 to 10 days post surgery, so that we can check whether your new kidney is functioning properly. At times, the new kidney might take some time to start functioning and produce urine. You might have to undergo dialysis till then and also take medications like diuretics to help the kidney expel excess water and salt from your body.
Our nurses and rehabilitation experts will take good care of you and guide you through your recovery.
We have state-of-the-art hemodialysis and peritoneal dialysis facility, complete with a water treatment plant to ensure high-quality dialysis for patients.
Do I need to follow-up after Kidney Transplant?
It is very important to visit your consulting doctor regularly and undergo all prescribed follow-ups and test to make sure that your new kidney is functioning well. Remember, a transplant surgery is a second chance at life and you need to be responsible for your own well-being.
What are bone marrow transplant and peripheral blood stem cell transplant?
Bone Marrow Transplant and Haematopoietic Stem cell Transplant are non-surgical modes of treatment to cure advanced stages of malignancies as well as non-malignant haematological diseases and multiple other disorders.
As the name suggests, bone marrow transplant and peripheral blood stem cell transplant mean replacing or restoring dysfunctional cells with healthy cells.The diseased cells in your body are first destroyed completely through conditioning therapy, which is inducing high doses of chemotherapy or irradiation.You’ll be then infused with healthy cells that will start multiplying on their own in about 2 to 3 weeks.
What are the different types of Bone Marrow Transplants?
There are three types of Bone Marrow Transplants based on from who the donor cells are harvested
Autologous transplant is when you are receive your own stem cells.
Allogeneic transplants in when you receive cells donated by your sibling or parent. However, an unrelated donor or a person who is not related to you can also give you stem cells for transplant.
Syngeneic transplant is when you are infused with stem cells donated by your identical twin.
What are bone marrow and hematopoietic cells?
Bone marrow is the soft, sponge-like material found inside your bones and contains immature cells known as hematopoietic or blood-forming cells. The Hematopoietic cells keep dividing into more blood-forming cells; and mature into one of three types of blood cells: infection-fighting white blood cells, oxygen-carrying red blood cells and clot-forming platelets.
Though most hematopoietic stem cells are found in the bone marrow, some cells called peripheral blood stem cells are found in your bloodstream. Blood in the umbilical cord also contains hematopoietic cells. Cells from any of these sources can also be used in transplant.
What is conditioning/ Chemotherapy and radiation therapy before bone Marrow Transplant and Peripheral Blood Stem Cell Transplant?
The first step to BMT and PBSCT is destroying the diseased cells from your body through high doses of chemotherapy or radiation called conditioning. At Aster Medcity, we have the most advanced technology for these procedures, including Kerala’s first True Beam Linear Accelerator and dedicated radiotherapy rooms to ensure maximum patient safety. All radiotherapy treatments we provide are based on NCCN (USA) and ESMO (Europe) guidelines.
As cancerous cells divide faster than healthier cells, we can, through conditioning destroy the existing bone marrow cells so that we can infuse healthy, transplanted cells into your body effectively.

